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A new 3-dimensional culture model of human liver tumor organoids to test immunotherapy antibody candidates

Project summary

Erasmus MC-University Medical Centre (Rotterdam) and Merus NV, a clinical-stage biotechnological company in Utrecht, develop a new technique to culture mini-tumors, that are grown from surgically resected human liver tumors, to study the effects of a novel class of immunotherapy antibody candidates for treatment of liver cancer.


Merus NV plans to develop its Biclonics® antibody candidates into clinical testing, and Erasmus MC aims to develop the novel culture technique into a diagnostic assay that permits precision medicine in which every liver cancer patient can be treated with the best therapy.

More detailed information

Principal Investigator:

Dr. Jaap Kwekkeboom

Role Erasmus MC:



Project website:

Funding Agency:

Top Sector Life Sciences & Health