Changes in brain DNA: Identifying RNA-templated DNA repair in human neurons.
Client :
Liquid Themes
Changes in brain DNA: Identifying RNA-templated DNA repair in human neurons.
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Project summary
To stay healthy, cells must repair their DNA. In most cells, DNA damage is preferentially repaired using a DNA-template to avoid mutations. However, neurons are thought to rely exclusively upon error-prone non-templated repair due to lack of a DNA copy synthesized during cell division. Because DNA is transcribed into RNA, we hypothesize RNA provides an alternative repair-template. Polymerase theta was shown recently to generate DNA from an RNA-template in dividing cells.
Impact
We will investigate if polymerase theta enables RNA-templated repair in human neurons, giving insight into the occurrence of (harmful) mutations and feasibility of therapeutic gene editing in the brain.
More detailed information
Principal Investigator:
dr. Juliette Kamp
Role Erasmus MC:
PI
Department:
Psychiatrie
Project website:
Funding Agency:
NWO
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