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Click on Target: Developing a Safe Drug with Enhanced Therapeutic Potential for Prostate Cancer Treatment

Project summary

Prostate cancer is the most common malignancy in men and the fifth cause of cancer-related death globally. Currently used imaging modalities and therapeutic options are still limited; especially for the detection and treatment of (oligo)metastatic disease, improvements are needed for more accurate detection and dedicated, precise treatment with a low toxicity profile. The aim of this preclinical project is to develop and evaluate a pretargeting strategy based on click-chemistry for safe and effective gastrin releasing peptide receptor (GRPR)-targeted radionuclide therapy.


This study is an essential step towards safe and effective use of GRPR-targeting radiopeptides for prostate cancer therapy, which will ultimately contribute to more cure and improved quality of life.

More detailed information

Principal Investigator:

Dr. Simone Dalm

Role Erasmus MC:



Project website:

Funding Agency:

KWF Kankerbestrijding /
Young Investigator Grant