Development of vascularised human kidney tissue in an animal free model
Kidney disease is affecting 10% of the world population and treatment options are limited. Novel technologies make it possible to generate mm-size kidney tissue from stem cells, so called kidney organoids, which are promising tools for drug testing, disease modelling and kidney repair. However, the current generation of kidney organoids has reached its limits in terms of size, maturation status and life-span due to a lack of blood flow through the organoids.
We aim at achieving long-term culture of mature kidney organoids by using an organ-on-chip platform developed by BI/OND that allows oxygen and nutrient-rich perfusion of kidney organoids without using animal models.
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Dr. Martin Hoogduijn
Role Erasmus MC: