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Guardians and caretakers of the genome

Project summary

The team wants to understand how the various DNA repair processes are interrelated. To be precise, they want to know how the molecular chaos of coincidental and dynamic interactions results in biological responses and cellular properties. It seems that everything that happens in a cell is random. At the same time, we now know that orderly repair processes can arise from this apparent chaos. How that is possible and how these processes are interrelated is the “avant-garde challenge” that the team is now tackling.


The team conducts fundamental research and therefore wants to understand in the first place how this all works, so that the importance of this knowledge for patients is not always immediately clear. At the same time, their fundamental discoveries are indeed relevant to medical practice.

More detailed information

Principal Investigator:

Claire Wyman, Jurgen Marteijn, Wim Vermeulen, Arnab Ray Chaudhuri, Joyce Lebbink, Roland Kanaar, Jan Hoeijmakers en Miao-Ping Chien

Role Erasmus MC:



Nano biology

Project website:

Funding Agency:

AMMODO Science award