DNA damage impedes transcription. This can result in severe cellular dysfunction and accelerated aging. An innovative microscopic analysis method will be used to study effects of DNA damage on transcription in living cells. Combined with advanced protein analysis, the scientists will study how cells cope with transcription-blocking DNA damage.
This project will significantly advance our knowledge on the cellular responses to TBLs, which is essential to understand their biological impact and role in DNA damage-induced aging, which could result in the development of future therapies that might alleviate age-related discomfort.