(Dam2Age) DNA Damage and Repair and its Impact on Healthy Ageing

Project summary

We pioneered an initially highly controversial connection between DNA damage and (accelerated) aging. In Dam2Age we will focus on the cross-talk between DNA damage, aging and DR with emphasis on the relevance for normal aging, elucidate underlying mechanisms and use our unique -for DR research superior- mouse models and a variety of novel assays to search for effective nutritional-pharmacological DR mimetics.

This project will serve as a stepping stone towards potent universal therapy for a range of repair-deficient progeroid syndromes and prevention of many aging-related diseases, most urgently dementia’s, to promote sustained health.