(Dam2Age) DNA Damage and Repair and its Impact on Healthy Ageing
![2017 - Hoeijmakers - Dam2Age ERC AdG](https://www.erasmusmc-rdo.nl/wp-content/uploads/2019/08/2017-Hoeijmakers-Dam2Age-ERC-AdG.png)
Project summary
We pioneered an initially highly controversial connection between DNA damage and (accelerated) aging. In Dam2Age we will focus on the cross-talk between DNA damage, aging and DR with emphasis on the relevance for normal aging, elucidate underlying mechanisms and use our unique -for DR research superior- mouse models and a variety of novel assays to search for effective nutritional-pharmacological DR mimetics.
Impact
This project will serve as a stepping stone towards potent universal therapy for a range of repair-deficient progeroid syndromes and prevention of many aging-related diseases, most urgently dementia’s, to promote sustained health.
More detailed information
Principal Investigator:
Role Erasmus MC:
Coordinator
Department:
Project website:
Funding Agency:
European Research Council (ERC) /
Advanced Grant
![ERC](https://www.erasmusmc-rdo.nl/wp-content/uploads/2019/08/ERC.jpg)