(RECODID) Integrated human data repositories for infectious disease-related international cohorts to foster personalized medicine approaches to infectious disease research

Project summary

EU-CAN-SHARE builds on existing infrastructures and partnerships to develop a sustainable model for the storage, curation, and analyses of the complex data sets collected by infectious disease (ID)-related cohorts. While ID cohorts collect both clinical-epidemiological (CE) and terabytes of OMICS data, storage and analysis of CE and high dimensional laboratory (HDL) data remains separate and developing the infrastructure for housing and analysing HDL data is not feasible for individual studies.  In this project, we develop innovative approaches to the synthesis and analysis of CE&HDL data, and modify governance models for cloud-based repositories elaborated by and for scientists in high-income countries to meet the specific challenges of synthesizing CE&HDL data and sharing data across international cohorts and with the Open Science community. We develop data architecture and governance that link biobanks to data repositories to facilitate equitable use, collaborative, cross-domain analyses, and replicability.

The cloud-based platform will provide analytic tools and computational power to facilitate cross-domain, collaborative analyses that inform personalized medicine approaches to diagnostic, treatment, and vaccine development in ID-focused international cohorts