Macrophage Targets for Metastatic Treatment (Mac4Me)

Project summary

The interplay between tumour cells and the host immune system is complex and involves a dynamic balance between immune-mediated tumour suppression and tumour-driven immune evasion. Understanding these local interactions at an early timepoint of metastatic invasion is crucial for the development of immunotherapies and for targeting advanced metastatic disease. With the support of the Marie Skłodowska-Curie Actions programme, the Mac4Me project will investigate tumour cell-immune host interactions at metastatic sites through a multidisciplinary approach.

The consortium will develop innovative organ-on-chip systems to model early metastasis in brain, bone, and liver and integrate preclinical data with clinical findings to identify new immune targets with AI. Moreover, the project will train societal and basic science doctorate candidates in participatory science.