Dissecting the mechanisms of malignant transformation in del(5q) myelodysplastic syndrome to selectively target the disease-initiating hematopoietic stem cells
Myelodysplastic syndrome (MDS) patients have an increased risk of leukemia. This project investigates the mechanisms of malignant transformation of hematopoietic cells containing a del(5q) mutation.
This project will generate new knowledge that may lead to the development of novel drugs targeting MDS without affecting healthy hematopoietic cells, ultimately increasing the therapeutic window in leukemia.
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Role Erasmus MC:
KWF Kankerbestrijding /
Young Investigator Grant