MRI to fingerprint dementia CHIME: Cerebral HemodynamIcs, Metabolism and clEarance: A comprehensive, non-invasive brain imaging approach to characterize key biological processes in dementia

Project summary

There are 55 million people worldwide with dementia, a brain disorder that can be caused by a variety of diseases and is still incurable. The underlying disease processes often begin decades before the first symptoms of dementia appear. The CHIME consortium aims to find clues in these early disease processes for timely diagnosis and treatment. To achieve this, the researchers are developing MRI-based technologies that visualise three important interrelated processes: changes in blood flow, metabolic processes and the removal of waste materials.

In this way, they hope to find biomarkers that will improve both the development of new drugs and the diagnosis, prognosis and monitoring of dementia patients.