MRI to fingerprint dementia CHIME: Cerebral HemodynamIcs, Metabolism and clEarance: A comprehensive, non-invasive brain imaging approach to characterize key biological processes in dementia
Client :
Liquid Themes
MRI to fingerprint dementia CHIME: Cerebral HemodynamIcs, Metabolism and clEarance: A comprehensive, non-invasive brain imaging approach to characterize key biological processes in dementia
Project summary
There are 55 million people worldwide with dementia, a brain disorder that can be caused by a variety of diseases and is still incurable. The underlying disease processes often begin decades before the first symptoms of dementia appear. The CHIME consortium aims to find clues in these early disease processes for timely diagnosis and treatment. To achieve this, the researchers are developing MRI-based technologies that visualise three important interrelated processes: changes in blood flow, metabolic processes and the removal of waste materials.
Impact
In this way, they hope to find biomarkers that will improve both the development of new drugs and the diagnosis, prognosis and monitoring of dementia patients.
More detailed information
Principal Investigator:
Esther Bron & Mijke Vernooij
Role Erasmus MC:
Beneficiery
Department:
Radiologie en Nucleaire Geneeskunde
Project website:
Funding Agency:
NWO