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(PERFORM) Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union

Project summary

The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they are suffering from self-resolving viral infection.

We aim to improve diagnosis and management of febrile patients, by application of sophisticated phenotypic, transcriptomic (genomic, proteomic) and bioinformatic approaches to well characterised large-scale, multi-national patient cohorts already recruited with EU funding.


PERFORM will develop a comprehensive management plan for febrile patients, capable of being rolled out in different healthcare systems across Europe, by linking sophisticated new genomic and proteomic approaches to careful clinical phenotyping, and building on pilot data from previous studies

More detailed information

Principal Investigator:

Prof. dr. Jan Hazelzet

Role Erasmus MC:



Project website:

Funding Agency:

Horizon 2020