In the Netherlands, ≥90% of the disease burden in the population is from non-communicable diseases. Complex genetic and environmental factors contribute to the development of many of these diseases. To develop effective prevention and treatment interventions, we need to be able to study the physiological mechanisms that link these genetic associations with the disease phenotypes. The overall aim of this project is the development of a robust and reliable framework for induced pluripotent stem cells (iPSCs) models for population-based studies.
This project will be among the first to investigate established iPSC methods in a longitudinal setting, with the potential to study the bounds of established iPSC models in this setting and to expand these iPSCs into experimental studies of disease etiology that have not been feasible up to this point.