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Beyond the window of risk?
Psychiatric and functional outcome in adult bipolar offspring, a longitudinal study

Project summary

Bipolar disorder (BD) is a severe mood disorder characterized by episodes of depression and (hypo)mania. One of the key challenges in the field of BD is early identification and adequate treatment during adolescence and young adulthood -a crucial time window for interpersonal and psychosocial development. The strongest risk factor for BD is having a parent affected with BD. In this project, I will study the development of BD in those with the highest risk by conducting the 20-year follow-up of the Dutch Bipolar Offspring cohort.


This project has the potential to identify targets for early detection and optimal treatment of UD and BD and contribute to the development of preventive strategies in a high risk population.

More detailed information

Principal Investigator:

Dr. Esther Mesman

Role Erasmus MC:



Project website:

Funding Agency: