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(CIRDinnova) Shifting the limits of resuscitation with “CIRD Controlled Integrated Resuscitation Device”

Project summary

Sudden cardiac arrest is one of the most frequent causes of death. But only 3% of the patients survive out-of-hospital resuscitation, and only 18% survive in-hospital resuscitation. Today the time-frame for successful resuscitation is only about 3 to 5 minutes after cardiac arrest. Thereafter, with every minute a rapid decline in survival is observed, tending to “zero” beyond ten minutes of CPR. For decades no significant improvement of the clinical outcome and no significant scientific progress in resuscitation could be shown! More than 10 years ago a research group led by the international renowned cardiac surgeon Prof F Beyersdorf at the Freiburg University Hospital started intensive clinical R&D to develop a completely new therapeutic concept for resuscitation. The designation for the therapy is “CARL – Controlled Automated Reperfusion of the whoLe body”.


The new therapeutic concept enables a game changing breakthrough in resuscitation therapy. It is patient-individual and introduces for the first time a controlled, automated and personalized medical therapy in emergency medicine.

More detailed information

Principal Investigator:

Dr. Dinis Reis Miranda

Role Erasmus MC:



Project website:

Funding Agency:

Horizon 2020