The enterovirus’s guide to the central nervous system—how to infect, spread, and trigger inflammation in brain cells

Project summary

Enteroviruses infect millions of people annually and can cause a broad range of severe and life-threatening neurological diseases. It is unknown which brain cells enteroviruses infect, how enteroviruses spread through the brain and how brain cells react to the virus infection. Here, I will study which specific brain cells are infected by enteroviruses and how these viruses travel from cell to cell. This project is an essential stepping stone to understand enterovirus-induced neurological complications and will help in the development of antivirals.