The front page: early transcriptional regulation of host-pathogen interaction

Project summary

While wild-type poliovirus is almost eradicated, other related enteroviruses have emerged, that can also lead to a sudden paralysis in children. This happens when motor neurons are affected by the virus. In this project the scientist will investigate the first responses when an enterovirus infects motor neurons with a novel combination of techniques from the field of genetics and virology. This research aims at understanding how motor neurons change their behaviour during infection. This will help us to elucidate how enterovirus causes paralysis.