Who puts the cohesin clamp on the genome and where?

Project summary

The human genome is folded and packed within the cell nucleus to allow precise switching between on and off states of genes. This folding is achieved by cohesin, a mobile DNA clamp. We want to investigate where in the genome the clamp is put on first. For this we have developed a method to look back in time and show which parts of the DNA cohesin has touched while moving along the DNA strand. We also ask which proteins are helping the cohesin clamp and localize them along cohesin’s walking track.