Pentoxifylline for sepsis in preterm infants: Rediscovery of an old drug for a new indication

Project summary

Infections can make premature babies seriously ill (= sepsis). Sepsis is life threatening and newborns who survive this regularly have serious residual symptoms. Antibiotic treatment alone is often insufficient.
The drug pentoxifylline is registered for the treatment of peripheral vascular circulation problems in adults. In this project, Sinno Simons and colleagues will investigate whether adding pentoxifylline to regular treatment leads to a better recovery of prematurely born children with sepsis.

The research aims to determine how and in which dosage this medicine works best in this group of newborns.